The analysis of host-cell proteins (HCPs) is a route to more fine-grained insights into cell
culture and purification of existing products and is likely to aid development of new
modalities such as cell therapies. Proteomics technologies, particularly liquid
chromatography – mass spectrometry (LC-MS) approaches, enable HCP analysis, and
their availability will allow more routine characterization of HCPs that may pose
challenges to the industry and development of new methods for HCP analysis.
This project team
proposes the creation of a NIIMBL Center of Excellence in HCPs that can support the
development and testing of state-of-the-art and emerging methods for HCP analysis using
mass spectrometry. Such a Center can also serve as a NIIMBL "core facility" for
performing HCP analysis in support of NIIMBL Projects and Organizations.
Standardized mass spectrometry-based methods for HCP detection
Support for routine HCP analysis
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University of Delaware
