Project category: Proteins/ Antibodies

An Integrated Platform for Fully Automated, Continuous, & Real-Time Multi-Attributes Monitoring of Upstream Processes for Glycosylated Monoclonal Antibodies Production

Cell Culture Glycosylation Multi-scale Data Driven Mechanistic Modeling (Phase 2)

Antibody mix-and-read assays based on fluorescence intensity probes

Commercial Deployment of Integrated PAT Technologies to Enable Continuous Upstream Production of Glycosylated Monoclonal Antibodies

Protein A Chromatography Multi-scale Data Driven/Mechanistic Modeling (Phase 2)

Evaluation of next generation sequencing (NGS) as a rapid, alternative assay for in vivo and in vitro adventitious virus testing for vaccine safety

Monoclonal Antibody Expression in Fast Alternative Hosts: Demonstration & Reference Material

Production of NIIMBL’s Antibodies in the Thermothelomyces Heterothallica Cl Expression System

Developing Directive Documents for Adoption of the NISTCHO Cell Line for Biomanufacturing Workforce Training

Software and Hardware Tools for Pharmaceutical Lyophilization Scale-up

Continuous Countercurrent Spiral Chromatography (CCSC) – Feasibility, Demonstration and Commercialization

Use of Metabolic Flux Analysis (MFA) to Expedite Media Selection and Optimization of CHO