Current industrial practice includes frequent solution sampling and sensor probe calibration in order to monitor solution status such as pH and glucose.
Short wavelength infrared (SWIR) hyperspectral imaging has the potential to offer non-invasive and continuous monitoring solution status to cut labor cost and sampling waste in the processing lines.
Automated system for in-line, non-invasive, self-calibrated pH and/or related DO and glucose measurement in pharmaceutical processing.
Hevaganinge, A., Weber, C. M., Filatova, A., Musser, A., Neri, A., Conway, J., Yuan, Y., Cattaneo, M., Clyne, A. M., & Tao, Y. (2023). Fast-Training Deep Learning Algorithm for Multiplex Quantification of Mammalian Bioproduction Metabolites via Contactless Short-Wave Infrared Hyperspectral Sensing. ACS Omega, 8(16), 14774-14783. https://doi.org/10.1021/acsomega.3c00861
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University of Maryland College Park
Artemis Biosystems Inc.
Genentech, Inc.
